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Inhalation exposure of diamond nanoparticle induced oxidative stress in melanoma

عنوان مقاله: Inhalation exposure of diamond nanoparticle induced oxidative stress in melanoma
شناسه ملی مقاله: IPMCMED02_054
منتشر شده در دومین کنگره بین المللی پزشکی شخصی در سال 1396
مشخصات نویسندگان مقاله:

Maryam mirzaei - Islamic Azad University of Medical Science Tehran,iran
Parvane Naserzadeh - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, P.O. Box ۱۴۱۵۵-۶۱۵۳, Tehran, Iran
Mehrdad Hashemi - Department of medical biotechnology Tehran Medical Science brunch Islamic azad university Tehran,iran

خلاصه مقاله:
1. With the ever-increasing use of (Diamond) in health-related and engineering applications, the hazardous risks of this material have become a major concern. It is well known that diamond accumulate with cytotoxic and genotoxic levels within vital organs. It has also been shown that treating cell cultures with diamond resulted in cell cycle arrest and increased apoptosis/necrosis.2. In this study, we investigated chronic exposed to diamond at the exposure chamber in mice. The animals were divided into two groups (control and exposed group to diamond at the concentration of 3 µg/m3 for 5 h/day,) in a whole-body inhalation chamber.3. Our results showed that exposure to diamond induced the hematological and biochemical changes. The target organs for diamond were the melanoma in the mice, respectively. Also, NPs increased reactive oxygen species (ROS) generation, lipid peroxidation (LPO), the collapse of mitochondrial membrane potential (MMP), decreased a level of reduced glutathione (GSH) and finally increased a level of glutathione disulfide (GSSG) in melanoma tissues. Our results suggest that exposure to diamond can induce oxidative stress in the tissue mentioned.4. These results suggest that exposure of researchers and workers with diamond probably increase a risk of respiratory, cardiovascular and cerebral disorders through oxidative stress. However, good ventilation, appropriate personal protective equipment and using of anti-oxidant compounds in daily diet of worker are suggested.

کلمات کلیدی:
Diamond, chronic exposure, oxidative stress, reactive oxygen spices

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/714129/