Mohammad Reza Zali - Professor of Gastroenterology, Research Institute for Gastroenterology and Liver, Shahid Beheshti University of Medical Sciences

Medicine is now developing as personalized solutions for a particular patient’s needs, and there is a cumulative attention to personalized medicine. Personalized medicine is an extensive field of healthcare subjects which is informed by each person s unique clinical, genetic, genomic, and environmental information. Considerable progresses have taken place in biomedical science to make personalized medicine a feasible option. The translation of human genome information to clinical medicine needs answering three following questions: Which molecular factors are involved in the pathogenesis of a particular disease Which individuals or patients will develop a particular disease How a therapeutic regimen is developed that can be personalized to an individual with a unique biology In gastroenterology, personalized medicine is mostly applied for management inflammatory bowel diseases, gastrointestinal malignancies, H. pylori associated diseases, and many other diseases. Study of microbioma structures in different people is an attractive field in personalized medicine. Pathogenesis and manifestation of gastroenterology and liver diseases are a direct result of the interaction of the human genome and the bacterial genome. In this regards, the characteristics of the host s intestinal microflora is tremendously significant when beginning treatment of gastroenterology diseases because composition of gut microflora varies between different individuals. Applications of personalized medicine for the gastroenterology disorders are including: employment of novel therapeutic approaches, optimization of therapy, study of drug toxicity, development of efficient biomarkers for early detection of disease, identification of markers of response to therapy and study of virulency.