Alireza Bayat - Aja University of Medical Sciences
Amirreza Sanie Poor - Aja University of Medical Sciences
Aref Shirvani Saadat Abadi - Aja University of Medical Sciences
Parvin Zareian - Aja University of Medical Sciences

According to Carnation widely used in traditional medicine in countries like Iran, China andEgypt and the widespread prevalence of cancer and current treatment methods and theeffects of favorable performance over chemical drugs, the need to replace this plant withfewer side effects are feeling. The aim of this study was to evaluate the therapeutic effects ofclove extract on the growth and proliferation of cancer cells The studies in this area haveshown that ethanol extract and oil of cloves has a lethal effect on breast cancer cells and alsothe composition of the ethanol extract and dried cloves avoid of cancer cell growth in breast,ovarian, cervical, liver and pancreatic. In addition, extracts of cloves increased Bax and P53pre-apoptotic proteins gene expression and downregulation of anti-apoptotic proteinsresponsible for cell proliferation BCL_2, viz, cox_2, cMyc, Hras .the The clove extractcompared with the anticancer drug gemcitabine (GEMCITABIN) has greater cytotoxic effecton cancer cells and less toxic effects on normal cells of the body.

Cancer, Carnation, Carnation Ethanol Extracts, Aqueous Extracts of Cloves, Oil of Cloves