Parvin Khodarahmi - Department of Biology, Parand Branch, Azad Islamic University, Tehran

It has been suggested that histamine have modulatory influence on anxiety-related behaviors both in animals and humans. In the present study, we investigated the effects receptor Antagonist Ranitidine on anxiety-related behaviors-of intraperitoneal of a H2 in rats, using elevated plus-maze test of anxiety Intraperitoneal ranitidine, a H2 mg/kg decreased %OAT (Open Arm 50 and 25 histamine receptor antagonist at doses of Times) and but not locomotor activity, thus showing an anxiogenic response Our results indicated that the anxiogenic-like effects induced by ranitidine in the intraperitoneal.

Ranitidine; Anxiety; Plus-maze test; Rat