The effects of Salvia Officinalis extract and antioxidant system in rat

Background and purpose: Studies on the relationship between the Salvia Officinalis extracts and tumor characteristics are relatively rare. The aim of this study is to investigate the effect of Salvia Officinalis extracts on the level of tumor associated marker called Carcinoembryonic Antigen in male rats.Methods: In this experiment 20 male Wistar rats were randomly divided into four groups of control, normal saline recipients, and Salvia Officinalis extract recipients (100 and 200 mg/kg body weight), each including 5 rats. Samples were subjected to laboratory experiments for seven weeks. Thereafter, blood samples were collected through cardiac puncture method, and following serum collection, the serum level of carcinoembryonic antigen was measured using radioimmunoassay method. Ultimately, the data was statistically analyzed and compared among distinct groups using one-way analysis of variance technique.Results: The results indicated that the serum level of carcinoembryonic antigen in the Salvia Officinalis extracts recipient group (200 mg / dl) was significantly lower than that of the control group (P = 0.007), although the serum levels of this antigen showed no significant variation in the group receiving Salvia Officinalis extracts with the dosage of 100 comparing to control.Conclusion: In general, the results of this study demonstrated that Salvia officinalis extract with appropriate dosage can reduce the serum levels of carcinoembryonic antigen. Accordingly, the pharmacological application of Salvia officinalis extract seems to be beneficial in treatment of cancers with elevated levels of this tumor marker.

Keywords:

Salvia officinalis – antioxidant system , Antigen and rat