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Title

Systems Biology Analysis of the Key Genes of Surfactin Production in Bacillus subtilis MJ01 (Isolated from Soil Contaminated Oil in South of Iran), Spizizenii, and 168 Isolates

Year: 1396
COI: JR_JCMR-9-2_006
Language: EnglishView: 235
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Authors

Tahereh Deihimi - Institute of Biotechnology, Shiraz University, Shiraz, Iran
Esmaeil Ebrahimie - Institute of Biotechnology, Shiraz University, Shiraz, Iran- Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia
Ali Niazi - Institute of Biotechnology, Shiraz University, Shiraz, Iran
Mansour Ebrahimie - Department of Biology, University of Qom, Qom, Iran
Shahab Ayatollahi - School of Chemical & Petroleum Engineering, Sharif University of Technology, Tehran, Iran
Ahmad Tahmasebi - Department of Crop Production & Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran

Abstract:

Applying microorganism in oil recovery has attracted attentions recently. Surfactin produced by Bacillus subtilis is widely used industrially in a range of industrial applications in pharmecutical and environmental sectors. Little information about molecular mechanism of suffactin compound is available. In this study, we performed promoter and network analysis of surfactin production genes in Bacillus subtilis subsp. MJ01 (isolated from oil contaminated soil in South of Iran), spizizenii and 168. Our analysis revealed that comQ and comX are the genes with sequencealterations among these three strains of Bacillus subtilis and are involved in surfactin production. Promoter analysis indicated that lrp, argR, rpoD, purr and ihf are overrepresented and have the highest number of transcription factor binding sites (TFBs) on the key surfactin production genes in all 3 strains. Also the pattern of TFBs among these three strains was completely different. Interestingly, there is distinct difference between 168, spizizenii and MJ01 in their frequency of TFs that activate genes involve in surfactin production. Attribute weighting algorithms and decision tree analysis revealed ihf, rpoD and flHCD as the most important TF among surfactin production. Network analysis identified two significant network modules. The first one consists of key genes involved in surfactin production and the second module includes key TFs, involved in regulation of surfactin production. Our findings enhance understanding the molecular mechanism of surfactin production through systems biology analysis.

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This Paper COI Code is JR_JCMR-9-2_006. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1004875/

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Deihimi, Tahereh and Ebrahimie, Esmaeil and Niazi, Ali and Ebrahimie, Mansour and Ayatollahi, Shahab and Tahmasebi, Ahmad,1396,Systems Biology Analysis of the Key Genes of Surfactin Production in Bacillus subtilis MJ01 (Isolated from Soil Contaminated Oil in South of Iran), Spizizenii, and 168 Isolates,https://civilica.com/doc/1004875

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Type of center: دانشگاه دولتی
Paper count: 21,774
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