Elham Rastegar - Department of Chemistry, Faculty of Science, Qeshm Branch, Islamic Azad University, Qeshm ,Iran.
Iman Khosravi - Department of Chemistry, Faculty of Science, Qeshm Branch, Islamic Azad University, Qeshm ,Iran
Farid Moeinpour - Department of Chemistry, Islamic Azad University–Bandar Abbas Branch, Bandar Abbas, Iran
Melika Eftekhari - Department of Chemistry, Faculty of Science, Qeshm Branch, Islamic Azad University, Qeshm ,Iran

In the study we reported synthesis of 2-aminothiophene derivatives in pure water using nano-structured Na2CaP2O7. Our results indicated that this heterogeneous catalyst performed good selectivity and catalytic activity in the synthesis of substituted 2- aminothiophene through Gewald reaction in water. The noticeable benefits of this procedure rely on several factors including: a simple method, mildness conditions, short time of reaction, operational simplicity and low cost.

2-Aminothiophenes, Gewald reaction, nanocatalyst, Na2CaP2O7