Effect of the Methyl beta cyclodextrin as the catalyst on the solubility rate of Sulfabenzamide

Sulfabenzamide (SBZ) is widely used in pharmaceuticals because of its antibacterial and antimicrobic properties. Sulfabenzamide is poorly water-soluble that improving solubility of poorly water-soluble drugs is one of the most emerging issues associated with these drugs to form a suitable dosage form that will provide a desired pharmacological response. Cyclodextrin modified nanoparticles are of great attention as they appreciably improve the characteristics of the catalytic properties. Cyclodextrin is capable of capturing a large number of organic molecules, of appropriate size and shape, to form the well-defined host-guest complex. Catalytic-based cyclodextrins as ligands such as methyl beta-cyclodextrin (M-β-CD) are water-soluble chemical receptors that have the ability to form an inclusion complex with drugs and can increase the water-solubility of organic substrates by inclusion into their hydrophobic cavity. Inclusion complex SBZ/ M-β-CD were prepared by freeze-drying (FD) methods in the 1:1 molar ratio on the basis of the results obtained from the phase solubility diagram. The phase-solubility diagram according to Higuchi and Connors method for the SBZ showed an increase in water solubility and the stability constant calculated: Kc= 56 M−1 with M-β-CD. The result of the complexation was characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (SEM), and Nuclear magnetic resonance (NMR).

Keywords:

Sulfabenzamide , M-β-CD , catalyst: Phase solubility , Inclusion complex , Spectroscopy