Mesoporous SBA-15/PIDA as efficient organocatalyst for three-component indazolophtalazine synthesis

Within the field of mesoscale nanoarchitecturing, ordered mesoporous silica SBA-15 has attracted increased interest in the recent years because of their unique properties including sharp pore distribution, high loading, and adjustable pore diameter 1. Due to these properties, numerous applications of these mesoporous silica in different fields have been explored including sensor, chromatography, drug delivery, energy storage and catalysis 2. Furthermore, mesoporous silica are relatively stable and easily functionalizable materials which make them ideal supports in catalytic processes 3. Herein, we have indicated a zwitterionic amino acid-like N-propyliminodiacetic acid (PIDA) organocatalyst supported to a heterogeneous surface (SBA-15/PIDA) based on iminodiacetic acid and mesoporous SBA-15. The mesoporous hybrid catalyst was successfully employed in the three-component reaction of dimedone, aldehydes and phtalhydrazide for the synthesis of indazolophtalazinetrione.