Significant Increasing of Gastrointestinal Dissolution of Aceclofenac via Florite
Publish place: Medbiotech Journal، Vol: 1، Issue: 1
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_MBT-1-1_002
تاریخ نمایه سازی: 10 خرداد 1399
Abstract:
It has been reported that about 40% of the compounds being developed by the pharmaceutical industries are poorly water soluble. The limiting factor to the in vivo performance of poorly water soluble drugs after oral administration their inadequate ability to be wetted by and dissolved into the fluid in the gastrointestinal (GI) tract. Therefore, increasing the dissolution rate of poorly water soluble drugs is an important and significant challenge to pharmaceutical scientists in order to maximize absorption. Aceclofenac is a nonsteroidal anti-inflamatory drug (NSAID), used for rheumatoid arthritis, osteoarthritis and other joint pains. The oral bioavailability of aceclofenac was found to be very poor likely due to the very poor dissolution in aqueous fluids especially in acidic medium. The study utilized the solvent evaporation method for preparation of stable amorphous solid dispersions of Aceclofenac by adsorbing it on porous carrier (Florite).
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Authors
Atefeh Mehrabifar
Cinnagen Pharmaceutical Company, Tehran, Iran
Mina Rahmati
Islamic Azad University Pharmaceutical Science Branch, Tehran, Iran