A comprehensive Review of Analytical Methods for the Determination of Aceclofenac in Biological Fluids and Pharmaceutical Dosage Forms
عنوان مقاله: A comprehensive Review of Analytical Methods for the Determination of Aceclofenac in Biological Fluids and Pharmaceutical Dosage Forms
شناسه ملی مقاله: JR_JCHM-2-3_006
منتشر شده در شماره 3 دوره 2 فصل در سال 1399
شناسه ملی مقاله: JR_JCHM-2-3_006
منتشر شده در شماره 3 دوره 2 فصل در سال 1399
مشخصات نویسندگان مقاله:
Ripple Parmar - Department of Quality Assurance, Pioneer Pharmacy Degree College, Nr. Ajwa Crossing, Sayajipura, Vadodara, Gujarat, India
Ritu Sapra - Department of Quality Assurance, Pioneer Pharmacy Degree College, Nr. Ajwa Crossing, Sayajipura, Vadodara, Gujarat, India
Prasanna Pradhan - Department of Quality Assurance, Pioneer Pharmacy Degree College, Nr. Ajwa Crossing, Sayajipura, Vadodara, Gujarat, India
Dhananjay Meshram - Department of Quality Assurance, Pioneer Pharmacy Degree College, Nr. Ajwa Crossing, Sayajipura, Vadodara, Gujarat, India
خلاصه مقاله:
Ripple Parmar - Department of Quality Assurance, Pioneer Pharmacy Degree College, Nr. Ajwa Crossing, Sayajipura, Vadodara, Gujarat, India
Ritu Sapra - Department of Quality Assurance, Pioneer Pharmacy Degree College, Nr. Ajwa Crossing, Sayajipura, Vadodara, Gujarat, India
Prasanna Pradhan - Department of Quality Assurance, Pioneer Pharmacy Degree College, Nr. Ajwa Crossing, Sayajipura, Vadodara, Gujarat, India
Dhananjay Meshram - Department of Quality Assurance, Pioneer Pharmacy Degree College, Nr. Ajwa Crossing, Sayajipura, Vadodara, Gujarat, India
Method development is the process to prove that the analytical methods employed to measure the concentration of active pharmaceutical drug in a particular compounded dosage form is acceptable. This must be validated to provide accurate data for regulatory submissions. Aceclofenac (ACE) is an analog of diclofenac, a non-steroidal anti-inflammatory drug (NSAIDs). The drug is used in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis ankylosing spondylitis, inflammation and relief of pain. The high importance of this class of drugs has prompted us to review the most important recent spectrophotometric methods for analyzing Aceclofenac in pure formulations, in various types of pharmaceutical dosage and in biological fluids published in the literature to date. They include spectrophotometry, high performance liquid chromatography, high performance thin layer chromatography, liquid chromatography-mass spectrometry, ultra high-performance liquid chromatography, mass spectrometry, and stability indicating methods.High sensitivity, speed, specificity and reproducibility make the use of these conventional methods for acetaminophen detection in routine analysis. They are time consuming, expensive and labour intensive though. Hence future research efforts are presumed to concentrate on developing novel methods to overcome these limitations.
کلمات کلیدی: Aceclofenac, NSAID, Estimation, Biological sample, Pharmaceutical formulations
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1021977/