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Title

Androgen Receptor Expression and Its Correlation with Clinicopathological Parameters in Iranian Patients with Triple Negative Breast Cancer

فصلنامه آسیب شناسی ایران، دوره: 15، شماره: 3
Year: 1399
COI: JR_IJP-15-3_013
Language: EnglishView: 230
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Authors

Azar Naimi - Department. of Pathology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Maryam Sultan - Department. of Pathology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Elham Amjadi - Department. of Pathology, Poursina Hakim Digestive Diseases Research Center, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Parvin Goli - Department. of Pathology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract:

Background & Objective: Our knowledge about correlation of androgen receptor expression and clinicopathological properties of triple-negative breast cancer (TNBC) patients is inadequate, particularly in the Iranian population. The main aim of the present study was to assess the AR expression in TNBC Iranian patients and evaluate its correlation with their clinicopathological parameters. Methods: Herein, 76 TNBC patients were evaluated for the AR expression by immunohistochemistry. The slides staining intensity was investigated according to the average degree of nuclear staining and sub-classified into negative (0), weak (1), moderate (2), or strong (3). Subsequently, the positive cells percentage for each slide was assessed and sub-classified into <25% (1), 25-50% (2), 50-75% (3), and > 75% (4). The aggregation of these two scores was used as the final score ranging from 0 to 7. While 4-7 scores were selected as positive, the others were included in the AR-negative expression group. Fisher s exact test was used to analyze the AR expression correlation with the clinicopathological parameters. Results: Positive immunoreactivity for AR was observed in 8 out of 76 (11%) specimens. No-correlation (P> 0.05) was observed between the AR expression and grade, stage, lymph node status, and Ki-67 level. The AR-positive patients exhibited older age at the time of diagnosis (P=0.0339) and larger tumor size (P=0.0224) in comparison with the AR-negative patients. Low percentage of TNBC patients expressed AR and no significant correlation was observed between its expression and most of the clinicopathological parameters. Conclusion: AR may not be a suitable biomarker and treatment target for the Iranian patients with TNBC.

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This Paper COI Code is JR_IJP-15-3_013. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1023056/

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Naimi, Azar and Sultan, Maryam and Amjadi, Elham and Goli, Parvin,1399,Androgen Receptor Expression and Its Correlation with Clinicopathological Parameters in Iranian Patients with Triple Negative Breast Cancer,https://civilica.com/doc/1023056

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Paper count: 4,527
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