Mandana Rafeey - MD, Professor, Liver and Gastrointestinal Diseases Research Center, Tabriz Cystic Fibrosis Registry, Tabriz University of Medical Sciences, Tabriz, Iran.
Zeinab Nikniaz - PhD, Assistant Professor, Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Fatemeh FarshiRadvar - MSc, Nutrition Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
Ziba Sameni - MD, Department of Pediatrics, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Cystic fibrosis (CF) is one of the most common genetic disorders in children. CF patients are susceptible to chronic lung infections and malabsorption. Although patient longevity is increased by multidisciplinary care, patients still suffer from respiratory failure and low quality of life. In this situation, CF patients tend to use complementary treatments. To the best of our knowledge there is no research about curcumin supplementation in CF patients; thus, we decided to investigate the effects of curcumin supplementation on anthropometric indices, and quality of life in children with cystic fibrosis. Materials and Methods This randomized control-controlled clinical study was conducted in Tabriz University of Medical Sciences, Iran. Forty CF patients were randomly sorted into intervention (n=20), and control (n=20) groups. Patients received 3 curcumin nanoparticles (80 mg; total dose 240 mg/d) for six consecutive months. Before and after intervention, height and weight were measured and quality of life of patients was evaluated by the Pediatric Quality of Life Inventory (PedsQL) 4.0 (CITE).  Results: After intervention, the percentage of weight changes showed a significant increase in the curcumin group compared to the control group (7.48±4.68 vs. 4.15±4.68 kg, p=0.03). Following the intervention, only the percentage of change in emotional functioning scores was significant (p=0.01).  Subjects in the curcumin group showed a trend towards more improvement in terms of percentage change in physical functioning (19.28±31.65 vs.  15.24±47.14), and school functioning scores (40.96±42.93 vs 23.90±14.82) compared with the control group.  Conclusion Our findings suggest that curcumin may be a useful, inexpensive, and safe supplement in combination with conventional therapy to improve body weight in CF children.

anthropometrics indices, Curcumin, Cystic fibrosis, Quality of life