Anti-inflammatory, antipyretic and analgesic activities of ethanol extract of Carica papaya

The aim of present study is to evaluate the anti-inflammatory, anti-pyretic ‎and analgesic activities of ethanol extract of Carica papaya L. on albino rats. ‎Plant of C. papaya L. is commonly used to treat ‎different diseases like fever, pain, and inflammation. A total of 144 albino rats ‎with an average weight of 160-200g were used in this study. Rats were divided into 4 ‎groups each group contained 12 rats. Anti-inflammatory activity was evaluated by ‎‎0.1 mL of 1% carrageenan extract that induces paw edema while analgesic activity ‎was investigated by acetic acid that induces abdominal writhing response where ‎antipyretic activity was demonstrated by yeast that induces pyrexia in rats. ‎In anti-inflammatory, antipyretic and analgesic activities, significant ‎results were shown at 400mg/kg, 50mg/kg and 400mg/kg doses respectively in ‎multiple comparisons. ‎The stem extract of C. papaya L. showed significant results as ‎compared to leaf extract in anti-inflammatory and antipyretic activities. The leaf ‎extract of C. papaya showed significant results as compared to the stem in analgesic ‎activity.‎

Keywords:

analgesic , Anti-inflammatory , Anti-pyretic , Carica papaya L , dicleofenac , leaf , Paracetamol , stem