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Title

Imatinib-loaded PEG-modified magnetic nanoparticles as an anti-cancer agent for pH responsive targeted drug delivery

Year: 1399
COI: ICMWMI01_010
Language: EnglishView: 356
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Abstract:

Targeted drug delivery is a promising approach to overcome the limitations of classical chemotherapy. In this respect, Imatinib-loaded PEG-modified magnetic nanoparticles were prepared as a pH sensitive system for targeted delivery of drug to tumor sites by applying a magnetic field. The proposed magnetic nanoparticles were prepared through modification of magnetic Fe3O4 nanoparticles with PEG400 and then Imatinib. The structural, morphological and physicochemical properties of the synthesized nanoparticles were determined by different analytical techniques including energy-dispersive X-ray spectroscopy (EDS), field emission scanning electron microscopy (FE-SEM), Fourier-transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), vibrating sample magnetometry (VSM), and X-ray diffraction (XRD). UV/visible spectrophotometry was used to measure the Imatinib contents. Drug loading and release profile of the prepared particles was investigated. The results demonstrated that Fe3O4@PEG acts as a pH responsive nanocarrier in releasing the loaded Imatinib molecules. Furthermore, the Fe3O4@PEG/Imatinib nanoparticles displayed cytotoxic effect against MCF-7 breast cancer cells.

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This Paper COI Code is ICMWMI01_010. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1030843/

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Shahriari, Marjan and Shahriari, Maryam,1399,Imatinib-loaded PEG-modified magnetic nanoparticles as an anti-cancer agent for pH responsive targeted drug delivery,International Conference on New Findings in Midwifery, Women, Childbirth and Infertility,https://civilica.com/doc/1030843

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COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

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