Mohammad Reza Aslani - Lung Inflammatory Diseases Research Center, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Somaieh Matin - Internal Medicine Department, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Ali Nemati - Biochemistry and Nutrition Department, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Mehran Mesgari Abbasi - Drug Applied Research Center, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Objective: Chronic obstructive pulmonary disease (COPD) is characterized by systemic inflammation and accelerated inflammaging of the lungs. Some studies showed that conjugated linoleic acid (CLA) has anti-inflammatory effects. The aim of the present study was to evaluate the effect of CLA supplementationon serum levels of interleukin (IL)-6 and sirtuin1 (SIRT1) in patients with COPD. Materials and Methods: 82 patients with stable COPD were enrolled in a double blind clinical trial. Subjects were randomly assigned to two groups: placebo (n=42) and 3.2 g CLA daily supplementation (n=40). Forced expiratory volume in one second (FEV1%), BODE index, and serum levels of IL-6, and SIRT1 were measured at the baseline and six weeks after the intervention. In addition, the study parameters in the two groups were compared based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. Results: After supplementation with CLA, serum levels of IL-6 and BODE index significantly decreased (p Conclusion: Supplementation with CLA can modify the inflammatory markers and improve the health status of COPD patients. The results suggest that CLA supplementation in COPD patients can be useful in the management of the disease.

Conjugated linoleic acid, COPD, Sirtuin 1, IL-6, BODE index