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Title

Organocatalytic enantioselective one-pot synthesis of β-aminoketones via Mannich reaction

Year: 1399
COI: JR_AJGC-4-3_002
Language: EnglishView: 127
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Authors

Madhavi S. Menkudle - Department of Chemistry, Dnyanopasak College, Parbhani-۴۳۱ ۴۰۱, MS, India
Avinash V. Chakrawar - Department of Chemistry, Dnyanopasak College, Parbhani-۴۳۱ ۴۰۱, MS, India
Prashant M. Kulkarni - Department of Chemistry, Dnyanopasak College, Parbhani-۴۳۱۴۰۱, MS, India
Wamanrao N. Jadhav - Department of Chemistry, Dnyanopasak College, Parbhani-۴۳۱۴۰۱, MS, India

Abstract:

An effective protocol for the asymmetric synthesis of β-amino carbonyl compounds using pyrrolidine based organocatalyst has been developed via one-pot three-component Mannich reaction. The organocatalyst (S)-N-(2,4-dinitrophenyl) pyrrolidine-2-carboxamide 3b confirmed to be the superior organocatalyst in solvent acetonitrile to obtain corresponding products in up to 89% yield and with excellent ee (90%). This organocatalytic reaction reveals productive result with a range of other aldehydes. Aromatic aldehydes having electron withdrawing substituent show the best results. Excellent yields, high enantioselectivity, mild reaction condition, and simple experimental work-up procedure are some of the advantages of this method.

Keywords:

Mannich reaction , Organocatalyst , β-amino carbonyl compounds Enantioselectivity , Multicomponent reaction

Paper COI Code

This Paper COI Code is JR_AJGC-4-3_002. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1032149/

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If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Menkudle, Madhavi S. and Chakrawar, Avinash V. and Kulkarni, Prashant M. and Jadhav, Wamanrao N.,1399,Organocatalytic enantioselective one-pot synthesis of β-aminoketones via Mannich reaction,https://civilica.com/doc/1032149

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