An efficient method for the synthesis of 4H-pyrans in magnetized distilled water

Magnetized distilled water (MDW), as a green solvent, was used in the three-componentsynthesis of 4H-pran condensation reactions of ethyl acetoacetate, malononitrile, and aldehydesunder catalyst-free conditions. The developed synthetic technique offers numerous advantagesincluding eco-friendly, simplicity, low-costs, short reaction times, high reaction yields, andeasy work-up compared to the traditional synthetic method.

Keywords:

4H-Pyran , Multi-component reaction , Catalyst-free , MDW