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Title

The Effect of Protelos Content on the Physicochemical, Mechanical and Biological Properties of Gelatin-Based Scaffolds

The Effect of Protelos Content on the Physicochemical, Mechanical and Biological Properties of Gelatin-Based Scaffolds
Year: 1399
COI: JR_JABR-7-1_006
Language: EnglishView: 165
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Authors

Seyyed Behnam Abdollahi Boraei - Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
Jhamak Nourmohammadi - Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
Behnaz Bakhshandeh - Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran
Mohammad Mehdi Dehghan - Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran|Institute of Biomedical Research, University of Tehran, Tehran, Iran

Abstract:

Introduction: Protelos (Pr) is a drug treatment for osteoporosis which reduces the risk of broken bones. The drug is unusual in that it both increases the deposition of new bone by osteoblasts and reduces the resorption of bone by osteoclasts. In this study, the effect of different amounts of Pr on the properties of gelatin-based scaffolds has been investigated. Materials and Methods: Halloysite nanotube (HNT) was used to control the release of Pr, while the HNT: Pr ratios changed. (2:1 (0.5-GHPr) and 1: 2 (2-GHPr)). For characterization of the scaffolds, the morphology, structure, mechanical behavior, and release behavior of this nanocomposite scaffold were studied. Also, cellular studies such as 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay, alkaline phosphatase (ALP) and calcium deposition of the nanocomposite scaffolds were investigated. Results: As a result, it can be stated that the 2-GHPr nanocomposite scaffold showed the best osteogenesis and release behavior between prepared scaffolds. In the case of mechanical properties, also 2-GHPr scaffolds had the best mechanical strength and modulus. Conclusions: According to the results, it can be mentioned that 2-GHPr composite scaffolds are a good choice in bone tissue engineering (TE).

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This Paper COI Code is JR_JABR-7-1_006. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1043493/

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Abdollahi Boraei, Seyyed Behnam and Nourmohammadi, Jhamak and Bakhshandeh, Behnaz and Dehghan, Mohammad Mehdi,1399,The Effect of Protelos Content on the Physicochemical, Mechanical and Biological Properties of Gelatin-Based Scaffolds,https://civilica.com/doc/1043493

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Type of center: دانشگاه دولتی
Paper count: 76,622
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