Study of Antidepressant Drugs Effect on Development of the Brain

Publish Year: 1399
نوع سند: مقاله کنفرانسی
زبان: English
View: 334

نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

ICIBS01_188

تاریخ نمایه سازی: 2 آذر 1399

Abstract:

Introduction: Depression, a mood disorder that causes a persistent feeling of sadness and loss of interest, is the most common mood disorder in the general population. This condition occurs twice as often in women as in men. The initial onset of depression peaks during a woman reproductive years. About 7% of pregnant women experience depression during pregnancy. Mothers using antidepressants during pregnancy may cause anxiety disorders in their children later in life because the drugs can interfere with the normal development of the fetal brain.Description: Human brain development is a protracted process that start in the third gestational week with the differentiation of the neural progenitor cells and continued for a few years after birth the brain continues to grow. The processes that guide brain development involve the ongoing interplay of genetic and environmental factors, like proper nutrition starting pregnancy, exposure to toxins or infections and the child experiences with other people and world. Brain tissue is characterized by high level of gene expressions and numerous anatomical changes during fetal and infancy development. Antidepressants have a similar mechanism of function and effects on the brain and may cause changes in brain structure. Some examples of antidepressant drugs are citalopram, fluoxetine, sertralin.Discussion and conclusion: Antidepressant drugs affects gene expression and brain development. Researches showed that mutation on genes that involved in neurogenesis like MCPH1, BDNF, ZNF335 or genes that have a role in Synaptogenesis such as SHANK3 can cause aberrant brain development. Mutation in centrosomal genes (CEP135, CEP152, CENPJ), tubbulin related genes (TUBB5,TUBA1,TUBB2B) and protein kinesin related genes (KIF14, KIF11) influences brain development and cause genetic brain disorders like primary microcephaly (MSPH), macrocephaly and autism.

Authors

Ramesh Ranjbar

Department of Biotechnology, faculty of Biological Sciencen and Technology, Shahid Ashrafi Esfahani University, Isfahan, Iran

Ali Mohammad Ahadi

Department of Genetics, Faculty of Science, Shahrekord University, Shahrekord, Iran

Zahra Zamanzade

Department of Biotechnology, faculty of Biological Sciencen and Technology, Shahid Ashrafi Esfahani University, Isfahan, Iran