The effect of Moringa olifera leaf extract on blood glucose in diabetic rats

Diabetes is a metabolic disorder caused by a defect in insulin secretion or both. Insulin Deficiency Increases Blood Glucose by Disrupting Carbohydrate, Fat, and Protein Metabolism with Diabetes, Vascular or Tissue Damage Causes Severe Complications of Diabetes they give.Thirty male Wistar rats weighing 200 ± 20 were divided into 6 groups of five. Group 1 (control), group 2 (diabetic), group 3 (diabetic + 100 dose mg / kg WB extract), group 4 (diabetic + 200 dose mg / kg WB extract), group 5 (diabetic + 400 dose extract), group 6 (diabetic + drug Metformin at a dose of 100). Diabetes was induced in animals by a single intraperitoneal injection of streptozotocin at a dose of 55 mg / kg WB rat body weight.The mean glucose concentration in the first group was 322.0 mg / dl which was 682.0 in the second group and 166.2, 493.6 and 448.5 in the 3, 4, 5 and 6 treatment groups, respectively and is 572.4. According to analysis of variance, the mean serum glucose concentration in group 1 was significantly different from group 2 (P <0.001). Also, the mean value of this parameter between group 2 and group 3, 4 and 5 had a significant difference at the 0.001 level.In this experiment, we observed an increase in glucose in group 2 compared to group 1 with the effect of Moringa olifera extract on diabetic groups treated with glucose compared to group 2, with a dose of 100 having the greatest effect on reducing glucose.

Keywords:

Diabetes , Moringa olifera , Extract , Anti-diabetic effect