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Paper
Title

Optimization of kinetic parameters of antibodyantigen binding reaction in microfluidic system

Year: 1399
COI: CARSE05_166
Language: EnglishView: 199
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Authors

Alireza Yari - Department of Chemical Engineering, Sharif University of Technology, Tehran, Iran,
Ehsan Heydarian dolatabadi - Department of Chemical Engineering, Sharif University of Technology, Tehran, Iran,

Abstract:

The optimization of the kinetic parameters is discussed and derived by simulating the antibody-antigen reaction in a microfluidic channel. A model is designed and used in COMSOL multiphysics with a 2D geometry to optimize the kinetics. The convectiondiffusionequations combined with diffusion-reaction equations develop a model to investigate the antibody-antigen complexes' concentration behavior. The monoclonal antibody (MAb) was immobilized on the microchannel wall surface, and the prostate specific antigen (PSA) was directed through the channel by the analyte solution. Theeffect of velocity and coated antibody was determined via a wide range of plots. Then the optimized velocity and antibody concentrations were derived after analyzing the data. Generally, the complex concentration rises and reaches equilibrium by increasing the velocity and decreasing the immobilized antibody concentration. The 2D simulation exhibited an excellent prediction for optimizing and obtaining accurate results.

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Paper COI Code

This Paper COI Code is CARSE05_166. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1128513/

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Yari, Alireza and Heydarian dolatabadi, Ehsan,1399,Optimization of kinetic parameters of antibodyantigen binding reaction in microfluidic system,5rd international conference on applied research in science and engineering,https://civilica.com/doc/1128513

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Type of center: دانشگاه دولتی
Paper count: 14,052
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