Copper-catalyzed amination of aryl halides in magnetized deionized water

In this work, a simple, green, and ligand-free approach to the copper-catalyzed N-arylation of secondary amines with aryl halides in magnetized deionized water (MDW), as a solvent, is introduced. This method offers the advantages of short reaction times, low costs, and an additive-free process, and it also enables new planning strategies for the construction of aryl amine-containing pharmacophores.

Keywords:

Aryl amine , Copper-catalyzed , Ligand-free , MDW