Evaluation of Wound Healing Effects of Scrophularia Striata Seed Extract in Rat

Introduction: Wound healing is a complex process that can be disrupted by different factors. Currently, there is no standard product to accelerate wound healing in incisional wounds. Acceleration of wound healing by Scrophularia striata (SS) hydroalcoholic extract was shown in previous studies. This study was designed to show the effect of SS seed aqueous extract on tissue tension and surface area of the healing wound in rats.   Methods: One hundred rats (Sprague Dawley -200±50 gr weight) were randomly assigned into 5 groups of 20 cases. Eucerin (negative control), phenytoin 1 percent cream (positive control), and SS root aqueous extract in Eucerin base (SSRE) 1 µg/ml, 10 µg/ml and 100 µg/ml. The incisional wound was inflicted on the spinal interscapular area. It was treated with substances on a daily basis. Tissue tension and the wound area was measured in all subjects.   Findings: In our study, the most tensile resistance of the healing wound was observed in group 4. Interestingly, group 4 showed the least surface area of the wound after the completion of the treatment period. Overall, there was a significant difference in wound healing process between groups that received SSRE treatment and other groups.   Conclusion: SSRE increases scar tissue endurance and improves wound healing. Early closure of the wound and increased tension endurance can help prevent future wound complications.

Keywords:

Scrophularia Striata , Sprague Dawley Rats , Phenytoin , Eucerin , Tissue Tension.