The Association between IL۶-۱۷۴ G/C Gene Polymorphism and Obesity: A Systematic Review and Meta-analysis

Background: The interaction between genetic and environmental factors has resulted in growing prevalence of obesity around the world. IL۶-۱۷۴ G/Cgene polymorphism is widely studied as the involved factor in developing obesity. Objectives: The aim of the present study is to evaluate the relationship between Interleukin ۶-۱۷۴ G/C promoter gene polymorphism and obesity in a systematic review and meta-analysis study. Methods: In the present study Science Direct,Medline, Embase, Google Scholar, PubMedand SID search engines have been searched until March ۲۰۱۶. Articles were evaluated using the key words IL۶ plus polymorphism or mutation or variant and adiposity, BMI and obesity. Data was analyzed using STATA software (۱۲th version). OR ratio was calculated with ۹۵% confidence interval to evaluate the strength in link between IL۶ gene and obesity. Heterogeneity was calculated using I۲ test. Articles bias was evaluated using funnel plot versus standard error (SE). The asymmetrydegree of the funnel plot was tested using linear regression tests ofEgger's and Begg's. Results: Generally, ۱۲ articles entered systematic review and ۶ articles entered final meta-analysis. After data was extracted, the total case group consisted of ۵۳۴۳ people and control group consisted of ۳۴۴۹ people. The odds ratio was estimated for additive model CC vs GC (OR= ۱; CI: ۹۵%: ۰/۹-۱/۱۲), recessive model CC + GC vs GG (OR= ۱/۰۴; CI: ۹۵%: ۰/۹۵- ۱/۱۵) and for dominant model (OR= ۱/۱۰; CI: ۹۵%: ۱-۱/۲۱). Also the results showed that there is a statistically significant relationship between IL-۶۱-۷۴ G/C gene polymorphism and obesity (P

Keywords:

IL۶ gene , meta , Analysis , Obesity