Effect of orally-administrated thymoquinone during pregnancy on litter size, pentylenetetrazol-induced seizure, and body weight in rat offspring
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 24، Issue: 1
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
View: 289
This Paper With 8 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJBMS-24-1_005
تاریخ نمایه سازی: 19 دی 1399
Abstract:
Objective(s): This study aimed to assess the impact of orally-administrated thymoquinone (TQ) during pregnancy on litter size, pentylenetetrazol-induced seizure, and body weight in rat offspring.Materials and Methods: In this experimental study, 64 pregnant rats were divided into groups according to the doses of TQ (0,10, 40, and 80 mg/kg) and gestational week (GW2 and GW3) of TQ administration. After parturition, the pups were counted, weighed, and assessed for pentylenetetrazol (PTZ)-induced seizure on postnatal days 14 (P14) and 21 (P21). Results: In GW2 treated rats, TQ 40 mg/kg decreased seizure stages compared with control only on P14 while seizure duration significantly decreased on P14 and P21. On P14, 40 mg/kg TQ increased latency to the first seizure but decreased it on P21. In addition, 40 mg/kg dose decreased body weight (BW) on P1, P14, and P21 compared with 10 mg/kg dose and control groups. The dose of 80 mg/kg led to a complete pregnancy loss. In GW3 treated rats, only 10 mg/kg TQ decreased the seizure stages on P14 and P21. None of the doses had a significant effect on seizure duration and latency. TQ 40 and 80 mg/kg led to a low birth weight while increased BW on P14 and P21. A 50% decrease in litter size was observed in 80 mg/kg treated rats. Conclusion: Prenatal TQ may have anticonvulsant effects. The effects of TQ on BW of offspring depend on its dose and administration time. Also, a high dose of TQ at GW2 can be severely toxic for pregnancy.
Keywords:
Authors
Amin Abdollahzade Fard
Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Ehsan Saboory
Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
Yaghob tahmazi
Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Yousef Rasmi
Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran
Sina Dindarian
Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
Negin Parsamanesh
Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :