ناشر تخصصی کنفرانس های ایران

لطفا کمی صبر نمایید

Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

Prophylactic effect of intranasal oxytocin on brain damage and neurological disorders in global cerebral ischemia in mice

Year: 1400
COI: JR_IJBMS-24-1_012
Language: EnglishView: 82
This Paper With 6 Page And PDF Format Ready To Download

Buy and Download

با استفاده از پرداخت اینترنتی بسیار سریع و ساده می توانید اصل این Paper را که دارای 6 صفحه است به صورت فایل PDF در اختیار داشته باشید.
آدرس ایمیل خود را در کادر زیر وارد نمایید:

Authors

Marzieh Saffari - Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran
Shahein Momenabadi - Department of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Abbas Ali Vafaei - Department of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Abedin Vakili - Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran
Mahdi Zahedi Khorasani - Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran

Abstract:

Objective(s): A few experimental studies have shown the therapeutic effects of oxytocin on focal cerebral ischemia. In this study, the prophylactic effect of intranasal oxytocin on brain damage was investigated in a cerebral ischemic model.Materials and Methods: Intranasal oxytocin (8 IU/per mouse) was prescribed daily for one week. Cerebral ischemia was performed through bilateral common carotid artery occlusion (BCCAO) for 20 min and then blood flow was restored for 24 hr. Finally, neurological disorders, spatial learning and memory, neuronal death, and neuronal apoptosis were assessed in CA1, CA3, and dentate gyrus. Also, levels of interleukin-1β (IL-1β) and Tumor necrosis factor-alpha (TNFα) were measured in the hippocampus.Results: Induction of global ischemia leads to neurological disorders and impairment of spatial learning and memory that are improved by pre-treatment with oxytocin (p <0.01). Cresyl violet staining showed that pretreatment with oxytocin significantly reduced the number of dead nerve cells in CA1, CA3, and dentate gyrus by 40.7, 32, and 34.3%, respectively. Also, positive TUNEL cells in CA1, CA3, and dental gyrus decreased by 15, 30, and 27%, respectively. In addition, levels of TNFα and IL-1β, which were extensively increased in ischemic mice, were significantly reduced with oxytocin pre-treatment. Conclusion: Pre-treatment of oxytocin reduces ischemic damage and improves neurological function and spatial memory. The neuroprotective effect of oxytocin is mediated by a decrease in cell death, apoptosis, and inflammatory mediators TNFα and IL-1β. Pre-treatment with oxytocin may be useful in people who are prone to stroke.

Keywords:

Apoptosis Interleukin , 1β Oxytocin Stroke Tumor necrosis factor

Paper COI Code

This Paper COI Code is JR_IJBMS-24-1_012. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1138574/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Saffari, Marzieh and Momenabadi, Shahein and Vafaei, Abbas Ali and Vakili, Abedin and Zahedi Khorasani, Mahdi,1400,Prophylactic effect of intranasal oxytocin on brain damage and neurological disorders in global cerebral ischemia in mice,https://civilica.com/doc/1138574

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :

  • 1. Hook V, Lietz CB, Podvin S, Cajka T, Fiehn ...
  • 2. Keshavarzi Z, Khaksari Hadad M, Zahedi MJ, Bahrami A. ...
  • 3. Ebrahimi SM, Aboutaleb N, Nobakht M. Consequences of ischemic ...
  • 4. Alimohamadi R, Fatemi I, Naderi S, Hakimizadeh E,   Rahmani ...
  • 5. Appelros P, Stegmayr B, Terént A. Sex differences in ...
  • 6. Zingg HH, Laporte SA. The oxytocin receptor. Trends Endocrinol ...
  • 7. Evans SL, Dal Monte O, Noble P, Averbeck BB. ...
  • 8. Erbas O, Korkmaz HA, Oltulu F, Aktug H, Yavasoglu ...
  • 9. Kaneko Y, Pappas C, Tajiri N, Borlongan CV. Oxytocin ...
  • 10. Moghadam SE, Tameh AA, Vahidinia Z, Atlasi MA, Bafrani ...
  • 11. Asadi Y, Gorjipour F, Behrouzifar S, Vakili A. Irisin ...
  • 12. Garcia JH, Wagner S, Liu KF, Hu Xj. Neurological ...
  • 13. Rahmati H, Momenabadi S, Vafaei AA, Bandegi AR, Mazaheri ...
  • 14. Akdemir A, Erbas O, Gode F, Ergenoglu M, Yeniel ...
  • 15. Gonzalez-Reyes A, Menaouar A, Yip D, Danalache B, Plante ...
  • 16. Momenabadi S, Vafaei AA, Bandegi AR, Zahedi-Khorasani M, Mazaheri ...
  • 17.    Karelina K, Stuller KA, Jarrett B, Zhang N, Wells ...
  • 18. Japundžić-Žigon N, Lozić M, Šarenac O, Murphy D. Vasopressin ...
  • 19. Dayi A, Cetin F, Sisman AR, Aksu I, Tas ...
  • 20. Wilkins HM, Swerdlow RH. TNFα in cerebral ischemia: another ...
  • 21. Olmos G, Lladó J. Tumor necrosis factor alpha: a ...
  • 22. Zaremba J, Losy J. Early TNF‐α levels correlate with ...
  • 23.    Rock KL, Latz E, Ontiveros F, Kono H. The ...
  • 24. Rothwell N. Interleukin-1 and neuronal injury: mechanisms, modification, and ...
  • 25. Hutchinson PJ, O’Connell MT, Rothwell NJ, Hopkins SJ, Nortje ...
  • 26. Arend WP. The balance between IL-1 and IL-1Ra in ...
  • 27. Emsley H, Smith C, Georgiou R, Vail A, Hopkins ...
  • 28. Oeckinghaus A, Ghosh S. The NF-κB family of transcription ...
  • 29. Lee JI, Burckart GJ. Nuclear factor kappa B: important ...
  • 30. Zhao H, Chen Z, Xie L-J, Liu G-F. Suppression ...
  • 31. Berti R, Williams AJ, Moffett JR, Hale SL, Velarde ...
  • 32. Khori V, Alizadeh AM, Khalighfard S, Heidarian Y, Khodayari ...
  • Research Info Management

    Certificate | Report | من نویسنده این مقاله هستم

    اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

    Scientometrics

    The specifications of the publisher center of this Paper are as follows:
    Type of center: علوم پزشکی
    Paper count: 924
    In the scientometrics section of CIVILICA, you can see the scientific ranking of the Iranian academic and research centers based on the statistics of indexed articles.

    Share this page

    More information about COI

    COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

    The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

    Support