Lettuce-avicularin treatment reverses insulin resistance through stimulation of glycolytic kinases and insulin signaling molecules
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 24، Issue: 2
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJBMS-24-2_014
تاریخ نمایه سازی: 19 دی 1399
Abstract:
Objective(s): In order to recommend a more effective approach to manage insulin resistance, we monitored the activities of glycolytic kinases, insulin signaling molecules, and incretin hormones and identified the possible targets related to the insulin-sensitizing effects of combined pharmacological and dietary intervention involving avicularin and lettuce.Materials and Methods: Insulin resistance was induced in rats with a fructose-rich diet and confirmed from baseline analysis of FBS (>250 mg/dl), insulin (>25 µIU/ml), and HOMA-IR (>10). For 12 weeks, the insulin-resistant rats were treated exclusively with 5000 mg/kg b.w avicularin (DAvi) or by dietary placement on lettuce (DLet) or a combination of both and compared with non-insulin resistant rats.Results: Avicularin reversed alterations in HbA1c and insulin levels. DLet produced no significant effect on the incretins GLP 1 (P=0.909) and GIP (P=0.990), but DAvi slightly stimulated GLP 1 but not GIP. A strong positive correlation was found between improved β-cell responsiveness and the insulin signaling molecules: Akt2 (r=0.7248), IRS 1 (r=0.5173), and PI3K (r=0.7892). Only the combined avicularin and lettuce reversed the Akt2 levels (P=0.728). The lettuce meal slightly stimulated PI3K but normalized IRS 1 while avicularin treatment slightly stimulated IRS 1 but restored the PI3K levels (P=0.815). The positive correlation between β-cell responsiveness and hexokinase (r=0.5959), PFK (r=0.6222), and PK (r=0.6591) activities were statistically significant. Alterations in glycolytic kinases were reversed by DLet and in combination with avicularin.Conclusion: A combined pharmacological and dietary approach with avicularin and lettuce is required to effectively reverse insulin resistance.
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Authors
Joy Amadi
Department of Nutrition and Dietetics, Imo State University Owerri, Imo State, Nigeria
Peter Amadi
Deparment of Biochemistry, Imo State University Owerri, Imo State, Nigeria
Uche Njoku
Department of Biochemistry, University of Port Harcourt, Choba, Rivers State, Nigeria
Chioma Onitchi
Deparment of Biochemistry, Imo State University Owerri, Imo State, Nigeria
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