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Title

Protective Effect of Oxytocin Against Bone Loss in a Female Rat Model of Osteoporosis

مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 9، شماره: 2
Year: 1399
COI: JR_RBMB-9-2_003
Language: EnglishView: 89
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Authors

Hoda Moghazy - Medical Physiology Department, Faculty of Medicine, Sohag University, Egypt
Aida Mahmoud - Medical Biochemistry Department, Faculty of Medicine, Sohag University, Egypt
Hala ElBadre - Medical Biochemistry Department, Faculty of Medicine, Assiut University, Egypt
Hekmat Osman Abdel Aziz - Histology Departments, Faculty of Medicine, Sohag University, Egypt

Abstract:

Background: Introduction: Oxytocin (OT) has been proposed to assist in the regulation of bone remodeling and to exert an antiosteoporotic effect. We evaluated the possible protective effect of OT against bone degeneration in ovariectomized (OVX) rats. Methods: The study was performed on three groups of adult female rats; group I was subjected to sham operation, group II was subjected to ovariectomy, and group III was subjected to ovariectomy and intraperitoneal injection with OT for eight successive weeks. At the end of the study, bone mass density (BMD) was measured; then the rats were euthanized and their blood and bone tissues were examined. Results: The group II rats had significantly less BMD and greater serum bone-specific alkaline phosphatase (bALP), osteocalcin (OC), and tartrate-resistant acid phosphatase (TRAP) levels than the group I rats. Furthermore, group II rats had fewer osteocytes and osteoblasts, and less OPG/RANKL mRNA expression than group I rats. The groups I and III and rats showed no significant differences in BMD, bALP, OC, TRAP, OPG/RANKL mRNA expression, or osteocyte and osteoblast numbers. Conclusions: Oxytocin may have an antiosteoporotic effect in OVX rats.

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This Paper COI Code is JR_RBMB-9-2_003. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

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Moghazy, Hoda and Mahmoud, Aida and ElBadre, Hala and Abdel Aziz, Hekmat Osman,1399,Protective Effect of Oxytocin Against Bone Loss in a Female Rat Model of Osteoporosis,https://civilica.com/doc/1141865

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