ناشر تخصصی کنفرانس های ایران

لطفا کمی صبر نمایید

Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

Analysis of Single Nucleotide Polymorphisms in HLA-DRA, IL2RA, and HMGB1 Genes in Multiple Sclerosis

Year: 1399
COI: JR_RBMB-9-2_010
Language: EnglishView: 92
This Paper With 10 Page And PDF Format Ready To Download

Buy and Download

با استفاده از پرداخت اینترنتی بسیار سریع و ساده می توانید اصل این Paper را که دارای 10 صفحه است به صورت فایل PDF در اختیار داشته باشید.
آدرس ایمیل خود را در کادر زیر وارد نمایید:

Authors

Mohsen Asouri - Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran & North Research Center, Pasteur Institute of Iran, Amol, Iran.
hamid Alinejad Rokni - Systems Biology and Health Data Analytics Lab, the Graduate School of Biomedical Engineering, UNSW Sydney, ۲۰۵۲, NSW, AU
Mohammad Ali Sahraian - Multiple Sclerosis Research Center; Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Sadegh Fattahi - North Research Center, Pasteur Institute of Iran, Amol, Iran
Nima Motamed - Department of Social Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Rozita Doosti - Multiple Sclerosis Research Center; Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Hamzeh Rahimi - Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
Maryam Lotfi - North Research Center, Pasteur Institute of Iran, Amol, Iran
Azam Moslemi - Department of Biostatistics, Faculty of Medical Sciences, Arak University of Medical Sciences, Arak, Iran
Morteza Karimpoor - Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
Fereidoun Mahboudi - Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
Haleh Akhavan-Niaki - Zoonoses Research Center, North Research Center, Pasteur Institute of Iran, Amol, Iran & Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran

Abstract:

Background: Multiple sclerosis (MS) is a common demyelinating neurodegenerative disorder with significant heritability. Previous studies have associated genetic variants in human leukocyte antigen (HLA) complex, IL2RA, and HMGB1 genes with the pathophysiology of MS. Methods: In order to investigate the gene association in the Iranian population, we performed a genotyping study of 36 variants in the mentioned genes using Sanger sequencing in 102 MS patients and 113 healthy controls. Results: Our results identified significant associations as well as significant allele frequency differences in some of the studied single-nucleotide polymorphisms including rs4935356, rs3177928, and rs7197 from HLA-DRA gene, and rs12722489 and rs12722490 variants from IL2RA gene (p< 0.05). Moreover, the strong linkage disequilibrium of two common haplotypes was estimated from the HLA-DRA gene. Conclusions: This association study may suggest the role of these polymorphisms in the genetic susceptibility of MS in the Iranian population and would facilitate the recognition of causative variants in this disease.

Keywords:

HMGB1, HLA-DRA, IL2RA, Multiple sclerosis, Polymorphism

Paper COI Code

This Paper COI Code is JR_RBMB-9-2_010. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1141872/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Asouri, Mohsen and Alinejad Rokni, hamid and Sahraian, Mohammad Ali and Fattahi, Sadegh and Motamed, Nima and Doosti, Rozita and Rahimi, Hamzeh and Lotfi, Maryam and Moslemi, Azam and Karimpoor, Morteza and Mahboudi, Fereidoun and Akhavan-Niaki, Haleh,1399,Analysis of Single Nucleotide Polymorphisms in HLA-DRA, IL2RA, and HMGB1 Genes in Multiple Sclerosis,https://civilica.com/doc/1141872

Research Info Management

Certificate | Report | من نویسنده این مقاله هستم

اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

Scientometrics

The specifications of the publisher center of this Paper are as follows:
Type of center: پژوهشگاه دولتی
Paper count: 804
In the scientometrics section of CIVILICA, you can see the scientific ranking of the Iranian academic and research centers based on the statistics of indexed articles.

Share this page

More information about COI

COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

Support