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Title

Serum Ischemia-Modified Albumin, Fibrinogen, High Sensitivity C- Reactive Proteins in Type-2 Diabetes Mellitus without Hypertension and Diabetes Mellitus with Hypertension: A Case-Control Study

مجله گزارش های بیوشیمی و زیست شناسی مولکولی، دوره: 9، شماره: 2
Year: 1399
COI: JR_RBMB-9-2_015
Language: EnglishView: 78
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Authors

Sushith Sushith - Department of Biochemistry, A. J. Institute of Medical Sciences and Research Centre, Mangaluru ۵۷۵۰۰۴, Karnataka, India
Herijenahalli Nagaraju Krishnamurthy - Department of Biochemistry, A. J. Institute of Medical Sciences and Research Centre, Mangaluru ۵۷۵۰۰۴, Karnataka, India
Shridhar Reshma - Department of Biochemistry, A. J. Institute of Medical Sciences and Research Centre, Mangaluru ۵۷۵۰۰۴, Karnataka, India
D'Sa Janice - Department of Biochemistry, A. J. Institute of Medical Sciences and Research Centre, Mangaluru ۵۷۵۰۰۴, Karnataka, India
Gopal Madan - Department of Biochemistry, A. J. Institute of Medical Sciences and Research Centre, Mangaluru ۵۷۵۰۰۴, Karnataka, India
Kumar Jeppu Ashok - Department of Biochemistry, A. J. Institute of Medical Sciences and Research Centre, Mangaluru ۵۷۵۰۰۴, Karnataka, India & International Medical School, Management and Science University, Shah Alam, Selangor ۴۰۱۰۰, Malaysia
Mangalore Balakrishna Prathima - Department of Biochemistry, A. J. Institute of Medical Sciences and Research Centre, Mangaluru ۵۷۵۰۰۴, Karnataka, India
Bhuvanesh Sukhlal Kalal - A. J. Research Centre, A. J. Institute of Medical Sciences and Research Centre, Mangaluru ۵۷۵۰۰۴, Karnataka, India & Ophthalmology, Visual & Anatomical Sciences, Wayne State University, Kresge Eye Institute, Detroit, Michigan ۴۸۲۰۱, United States of Ameri

Abstract:

Background: The objective of this study was to determine the levels of serum ischemia-modified albumin (IMA), fibrinogen (FIB) and high sensitivity C-reactive protein (hs-CRP) in type 2 diabetes mellitus (T2DM) patients with hypertension (HT) (DMT2HTN) and without HT (DMT2). Also, their association with certain biochemical and physical factors were studied to identify possible risk factors that lead to cardiovascular complications. Methods: Fasting blood samples were collected from 35 DMT2 or DMT2HTN patients each to analyze differences in serum and plasma levels of IMA, hs-CRP, FIB, total cholesterol (TC), high and low density lipoproteins (HDL and LDL), triglyceride (TG), hemoglobin A1c (HbA1C), glycated hemoglobin and creatinine. Results: In DMT2 and DMT2HTN patients, IMA, hs-CRP, FIB, TC, TG, HDL, LDL, glycated hemoglobin and creatinine levels, including body mass index (BMI) and waist-to-hip ratio (WHR), were significantly higher relative to healthy controls. In addition, the levels of IMA, hs-CRP and FIB levels showed a strong link to BMI, WHR, TC, TG, LDL and glycated hemoglobin. Lastly, both DMT2 and DMT2HTN patients demonstrated a significant reduction in HDL. Conclusions: DMT2 and DMT2HTN patients have a greater risk of developing cardiovascular related complications. This study suggests that quantifying hs-CRP, IMA and FIB levels can help diagnose the risk of developing complications during the early stages of metabolic and cardiovascular disease. Overall, the specific risk factors may be used for early identification of cardiovascular complications to decrease mortality and morbidity in T2DM patients.

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This Paper COI Code is JR_RBMB-9-2_015. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1141877/

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If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Sushith, Sushith and Krishnamurthy, Herijenahalli Nagaraju and Reshma, Shridhar and Janice, D'Sa and Madan, Gopal and Ashok, Kumar Jeppu and Prathima, Mangalore Balakrishna and Kalal, Bhuvanesh Sukhlal,1399,Serum Ischemia-Modified Albumin, Fibrinogen, High Sensitivity C- Reactive Proteins in Type-2 Diabetes Mellitus without Hypertension and Diabetes Mellitus with Hypertension: A Case-Control Study,https://civilica.com/doc/1141877

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