Revathi Panduranga Shenoy - Department of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education Manipal, Karnataka, India.
Gagana Hanumaiah - Department of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education Manipal, Karnataka, India.
Varashree Bolar Suryakanth - Department of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education Manipal, Karnataka, India.
Priyanka Shridharan - Department of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education Manipal, Karnataka, India.

Background: The study aims at the comparison and correlation of serum levels of fructosamine and erythrocyte Na+/ K+ ATPase in Gestational diabetes mellitus (GDM) and Non Gestational Diabetes Mellitus (Non GDM). Methods: A total of 326 samples were divided into 4 groups. Pregnant women between the age group of 20-40 years who gave samples for Oral Glucose Tolerance Test (OGTT) were included as the subjects. Anonymized and left over fasting and 2 hours’ samples were collected from biochemistry laboratory, Kasturba Hospital, Manipal. Results: In the comparison of fructosamine levels in GDM and Non GDM, fructosamine was found to be significant (p value<0.001) in both fasting and 2 hours (G2) blood glucose condition. Na+/ K+ ATPase did not show any significant variation between the groups. Correlation was not significant between the parameters. Conclusions: Fructosamine showed significant increase when compared between the groups, whereas significant correlation is not obtained between the parameters. Thus, the use fructosamine as a diagnosis tool becomes inconclusive. Further studies must be carried out to identify a marker which reduces the interferences observed in fructosamine and to find out the exact relationship between hyperglycaemia and Na+/ K+ ATPase activity.

Fructosamine, Gestational Diabetes Mellitus, Na+/ K+ Atpase Enzyme Activity, Screening Test