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Title

Induction of Specific Humoral Immune Response in Mice against a Pseudomonas aeruginosa Chimeric PilQ/PilA Protein

Year: 1397
COI: JR_RBMB-7-1_006
Language: EnglishView: 82
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Authors

Mehrdad Gholami - Department of Microbiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
Alireza Salimi Chirani - Department of Medical Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Reza Falak - Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran
Mona Moshiri - Division of Microbiology, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Shabnam Razavi - Department of Microbiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran & Microbial Biotechnology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Gholamreza Irajian* - Department of Microbiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran & Microbial Biotechnology Research Center, Iran University of Medical Sciences, Tehran, Iran.

Abstract:

Background: Pseudomonas aeruginosa, an opportunistic pathogen, is a common cause of healthcare-associated infections in immunocompromised individuals. The rapid emergence of multidrug-resistant strains has made P. aeruginosa infections progressively difficult to treat. In this study we evaluated the effect of a chimeric protein containing a P. aeruginosa PilQ fragment and the PilA disulfide loop (PilA-DSL) on the humoral immune response in BALB/c mice. Methods: A chimeric gene encoding an immunogenic region of PilQ and the PilA-DSL was synthesized. Following bacterial expression and purification, the protein was administered to mice and the humoral immune response analyzed. The resulting antibodies were analyzed using an opsonophagocytic killing assay. Results: The anti-recombinant protein antibody titer was significantly greater in immunized mice than in controls. In addition, antibody titers were significantly increased after booster immunizations, and the immunizations induced opsonophagocytosis of P. aeruginosa PAO1. Conclusions: These results suggest that an anti-adhesion-based vaccination may be effective in preventing P. aeruginosa infections. Further studies are needed to evaluate the abilities of such bivalent proteins to induce strong immune responses.

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This Paper COI Code is JR_RBMB-7-1_006. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1141973/

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Gholami, Mehrdad and Salimi Chirani, Alireza and Falak, Reza and Moshiri, Mona and Razavi, Shabnam and Irajian*, Gholamreza,1397,Induction of Specific Humoral Immune Response in Mice against a Pseudomonas aeruginosa Chimeric PilQ/PilA Protein,https://civilica.com/doc/1141973

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Type of center: علوم پزشکی
Paper count: 4,087
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