Assessment of Correlation Between miR-210 Expression and Pre-Eclampsia Risk: A Meta-Analysis

Background: Pre-eclampsia (PE) is a pregnancy disorder characterized by hypertension and proteinuria. The evidence has suggested that microRNAs (miRs) are associated with pre-eclampsia pathogenesis; however, these results are inconsistent. The aim of this study was to assess the association between miR-210 expression and PE risk. Methods: Previous studies were selected using PubMed, Scopus, MEDLINE, EMBASE, Science Direct, Google Scholar, Directory of Open Access Journals (DOAJ), and Scientific Information Database (SID). This meta-analysis includes 12 studies associated with miR-210 and pre-eclampsia and necessary information was extracted.    Results: The standardized mean differences [(SMD (0.32) 95% CI (014–0.49), p=0.97] and heterogeneity were determined with the chi-square test (Q=3.63 df =11 p= 0.97), which found no heterogeneity between these studies. Additionally, publication bias was evaluated by Egger’s and Begg´s tests. Visual inspection of the funnel plot graphically, and statistically with Egger’s weighted regression [(p= 0.35) (95% CI -0.90 – 2.29)] and Begg’s rank correlation (p= 0.21), found no important publication bias between studies within the meta-analysis. Conclusions: Our findings suggest that miR-210 contributes to the pathogenesis of PE; therefore, miR-210 could serve as a novel biomarker to predict PE pathophysiology. Further studies are required in this field to characterize the mechanism involved in this process.

Keywords:

Meta-analysis , MiR-210 , Pre-eclampsia