Measurement of TGFB۱ and JAK۲ Polymorphism in the Blood Cells of Iranian women with Recurrent miscarriage

Introduction and aim: Recurrent miscarriage is two or more consecutive pregnancy losses before weeks ۲۰. Different factors involved in recurrent abortion as a multifactorial disease. Genetic factors are one of the important factors associated with recurrent abortion. The goal of this article is to assess the association between single nucleotide polymorphisms of TGFB۱ and JAK۲ polymorphism and the recurrent miscarriage in Iranian women.
Methods: The study group was ۳۰ women with recurrent miscarriages with unknown reason and the control groups consisted of ۱۰ women with at least two successful pregnancies and no miscarriages. PCR was used to find the association between TGFB۱ and JAK۲ genes and recurrent miscarriages. Analysing performed with FinchTV software after data sequencing.
Results: Our results provided evidence that TGFB۱ polymorphisms influence the risk of recurrent abortion in the Iranian population however there is no correlation with JAK۲ polymorphism and recurrent abortion.
Conclusion: This finding could help to prevent recurrent miscarriage in Iranian women.

Keywords:

Blood Cells , Polymorphism , TGFB۱ , JAK۲ , Recurrent Abortion