Molybdenum Cofactor Biology and Disorders Related to Its Deficiency; A Review Study

Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
View: 298

This Paper With 12 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_JNFS-4-3_008

تاریخ نمایه سازی: 20 بهمن 1399

Abstract:

Background: Molybden, as a vital and essential micronutrient is directly involved in the metabolism of other elements including carbon, sulfur, and nitrogen. Molybdenum alone is not biologically active unless it binds to specific cofactors. Except for the bacterial nitrogenase, which contains molybdenum-Iron complex, molybdenum cofactor (Moco) is considered as the bioactive component placed in active site regions of molybdenum-containing enzymes. This review aimed to discuss the biological mechanisms involved in molybdenum metabolism highlighting Molybdenum cofactor deficiencies. Methods: Articles indexed in Pubmed, Google Scholar, and Scopus databases were used to extract the required information. Results: Moco, as the cofactor of sulfite oxidase, xanthine dehydrogenase, aldehyde oxidase, and nitrite reductase plays a substantial role in maintaining normal body homeostasis and reactive oxygen species (ROS) production. Lack of Moco is found to be associated with many inborn genetic disorders, such as mental retardation, brain immaturity, nervous shocks, and neurodegenerative diseases. Conclusion: Moco insufficiency compromises normal human body metabolism since it is reported to regulate the metabolic pathways of other elements. Although in recent years, substitution- and gene-therapies have been introduced to restore the metabolic pathways of patients with MoCD type A and B, the definitive treatment for this type of inborn disease has still remained ill-defined. More investigations are needed to completely understand the underlying pathophysiology of molybdenum-related diseases.

Authors

Navid Ghasemzadeh

Department of Clinical Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Elham Karimi-Nazari

Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Fatemeh Yaghoubi

Department of Clinical Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Sadegh Zarei

Department of Clinical Biochemistry, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Fatemeh Azadmanesh

Department of Clinical Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Javad Zavar Reza

Department of Clinical Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Saman Sargazi

Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Abbasalipourkabir R, et al. 2015. Toxicity of zinc oxide nanoparticles ...
  • Aguilar M, Cárdenas J & Fernández E 1992. Quantitation of ...
  • Atwal PS & Scaglia F 2016. Molybdenum cofactor deficiency. Molecular ...
  • Badwey J, Robinson JM, Karnovsky MJ & Karnovsky ML 1981. ...
  • Baxter I, et al. 2008. Variation in molybdenum content across ...
  • Belaidi AA & Schwarz G 2013. Metal insertion into the ...
  • Blasco F, et al. 1998. NarJ is a specific chaperone ...
  • Bortels H 1930. Molybdän als Katalysator bei der biologischen Stickstoffbindung. ...
  • Del Rizzo M, et al. 2013. Metabolic stroke in a ...
  • Dent C & Philpot G 1954. Xanthinuria: an inborn error ...
  • Duran M, et al. 1978. Combined deficiency of xanthine oxidase ...
  • Fräsdorf B, Radon C & Leimkühler S 2014. Characterization and ...
  • Hagen WR 2011. Cellular uptake of molybdenum and tungsten. Coordination ...
  • Hänsch R, et al. 2006. Plant sulfite oxidase as novel ...
  • Hille R 2002. Molybdenum enzymes containing the pyranopterin cofactor: an ...
  • Huang D-Y, Furukawa A & Ichikawa Y 1999. Molecular Cloning ...
  • Ichida K, Yoshida M, Sakuma R & Hosoya T 1998. ...
  • Kaiser WM & Huber SC 2001. Post‐translational regulation of nitrate ...
  • Kisker C, et al. 1997. Molecular basis of sulfite oxidase ...
  • Kramer S, Hageman RV & Rajagopalan K 1984. In vitro ...
  • Kurlemann G, Debus O & Schuierer G 1996. Dextrometorphan in ...
  • Lee H-J, et al. 2002. Molybdenum cofactor-deficient mice resemble the ...
  • Leimkühler S, Wuebbens MM & Rajagopalan K 2001. Characterization of ...
  • Lewis NJ, Hurt P, Sealy‐Lewis HM & Scazzocchio C 1978. ...
  • Mendel RR 2007. Biology of the molybdenum cofactor. Journal of ...
  • Mendel RR & Leimkühler S 2015. The biosynthesis of the ...
  • Nowak K, et al. 2004. Peroxisomal localization of sulfite oxidase ...
  • Parmeggiani B, et al. 2015. In vitro evidence that sulfite ...
  • Pau R & Lawson DM 2002. Transport, homeostasis, regulation, and ...
  • Paul BD, et al. 2014. Cystathionine γ-lyase deficiency mediates neurodegeneration ...
  • Rajagopalan K & Johnson J 1992. The pterin molybdenum cofactors. ...
  • Reiss J 2000. Genetics of molybdenum cofactor deficiency. Human Genetics. ...
  • Reiss J 2016. Molybdenum Cofactor and Sulfite Oxidase Deficiency. Journal ...
  • Reiss J & Johnson JL 2003. Mutations in the molybdenum ...
  • Rodríguez-Trelles F, Tarrío R & Ayala FJ 2003. Convergent neofunctionalization ...
  • Sanders SA, Eisenthal R & Harrison R 1997. NADH oxidase ...
  • Santamaria-Araujo JA, Wray V & Schwarz G 2012. Structure and ...
  • Schwahn BC, et al. 2015. Efficacy and safety of cyclic ...
  • Schwarz G 2016. Molybdenum cofactor and human disease. Current Opinion ...
  • Schwarz G, Mendel RR & Ribbe MW 2009. Molybdenum cofactors, ...
  • Schwarz G, et al. 2004. Rescue of lethal molybdenum cofactor ...
  • Scriver CR, Beaudet A, Sly W & Valle D 2001. ...
  • Shaw S & Jayatilleke E 1990. The role of aldehyde ...
  • Tejada-Jiménez M, Galván A & Fernández E 2011. Algae and ...
  • Terao M, et al. 2000. Cloning of the cDNAs coding ...
  • Tomatsu H, et al. 2007. An Arabidopsis thaliana high-affinity molybdate ...
  • Trigiano RN & Gray DJ 2004. Plant development and biotechnology. ...
  • Turnlund JR 2002. Molybdenum metabolism and requirements in humans. Metal ...
  • Tyagarajan SK & Fritschy J-M 2014. Gephyrin: a master regulator ...
  • Veldman A, et al. 2010. Successful treatment of molybdenum cofactor ...
  • Warner CK & Finnerty V 1981. Molybdenum hydroxylases in Drosophila. ...
  • Yesbergenova Z, et al. 2005. The plant Mo‐hydroxylases aldehyde oxidase ...
  • Zarei S, Moradi H, Asadi S, Aabbasalipourkabir R & Ziamajidi ...
  • Zhang X, Vincent AS, Halliwell B & Wong KP 2004. ...
  • نمایش کامل مراجع