Cytotoxic Activity of the Root of Euphorbia Tehranica Ethanolic Extract Against Caco-2 Colorectal Cancer Cell Line
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Introduction: Efforts are made to identify the new potential components such as anticancer drugs. Medicinal plants belonging to Euphorbia genus are widely studied with promising effects. The current study aimed at investigating the effect of ethanolic extract of the root of E. tehranica, grown in Iran, on Caco-2
human colorectal cancer cell-line.
Methods: The Caco-2
cells were treated with different concentrations of the root of E. tehranica ethanolic extract (25 to 1200 μg/mL) at 24 and 48 hours. Cell growth was evaluated with MTT assay. Anticancer activity of the ethanolic extract was assessed by evaluating the cell viability. Cell viability was determined at the wavelength of 570 nm by MTT method. The IC50 (half maximal inhibitory concentration) was determined graphically. One-way ANOVA followed by Tukey’s post-test; and P values <0.05 were considered statistically significant.
Results: The findings showed the significant cytotoxic effect of the root of E. tehranica ethanolic extract against Caco-2
cell-lines (P ≤0.05). Therefore, the viability of Caco-2
cells reduced with the dose and time-dependent manner, when compared with that of the control group. Also, the differences between the IC50 in 24 and 48 hours were 850 and 855 μg/mL, respectively.
Conclusions: It was the first study on the effect of the root of E. tehranica ethanolic extract on human colon cancer cell-lines. The results showed that this extract had the capacity to inhibit proliferation of tumor cells. Therefore, it seems to be a good candidate to defend against cancer cells.
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Forouzesh, Flora and Sadeghi, Vahideh and Baghaei, Kaveh and Rajabbeigi, Elham and Nazemalhosseini -Mojarad, Ehsan,1397,Cytotoxic Activity of the Root of Euphorbia Tehranica Ethanolic Extract Against Caco-2 Colorectal Cancer Cell Line,https://civilica.com/doc/1154175
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1. Gruenwald J. The Global Herbs & Botanicals Market. http://www.nutraceuticalsworld.com/issues/2008-07/view_features/the-global-herbs-amp-botanicalsmarket/. ...2. Altundağ E, Öztürk M. Ethnomedicinal studies on the plant resources ...3. Tang Q, Su Z, Han Z, Ma X, Xu D, ...4. Jassbi AR. Chemistry and biological activity of secondary metabolites in ...5. Shi QW, Su XH, Kiyota H. Chemical and pharmacological research ...6. Parsa A. Euphorbiaceae. Flore de l’ Iran, Tehran. 1949;4:1206-84. ...7. Pahlevani AH. Euphorbia prostrata, a noteworthy new record from the ...8. Akhani H. A new spiny, cushion-like Euphorbia (Euphorbiaceae) from south-west ...9. Rechinger KH, Schiman-Czeika H. Euphorbiaceae. Flora Iranica, Flora Iranica.Lfg.006: 1964; ...10. Mobayen S. Rostanihaye Iran. Tehran University press. 1979;2:85-151. Google Scholar. ...11. Nasseh Y, Joharchi MR. New records and interesting taxa of ...12. Nasseh Y, Joharchi MR, Zehzad B. Two new records of ...13. Rechinger K.H. Euphorbia. In: Flora Iranica, Euphorbiacea. No 6 Edits. ...14. World Health Organization. Cancer Incidence in Five Continents. Lyon: The ...15. Boyle P, Langman JS. ABC of colorectal cancer: Epidemiology. BMJ. ...16. World Cancer Research Fund and American Institute for Cancer Research. ...17. Fakheri H, Janbabai G, Bari Z, Eshgi F. The epidemiologic ...18. Haghdoost AA, Chamani G, Zarei MR, Rad MB, Hashemipoor M, ...19. Moghimi-Dehkordi B, Safaee A, Zali MR. Prognostic factors in 1,138 ...20. Dolatkhah R, Somi MH, Bonyadi MJ, Kermani IA, Farassati F, ...21. Janout V, Kolla´rova´ H. Epidemiology of colorectal cancer. Biomed Pap ...22. U.S. Cancer Statistics Working Group. United States Cancer Statistics: 1999–2005 ...23. Özbilgin S, Çitoğlu G. Use of some Euphorbia species in ...24. Whelan L. C, Ryan MF. Ethanolic extracts of Euphorbia and ...25. Louis KS, Siegel AC, Levy GA. Comparison of manual versus ...26. Bankova V. Natural products chemistry in the third millennium. Chem ...27. Manach C, Hubert J, Llorach R, Scalbert A. The complex ...28. Li C, Wang MH. In vitro biological evaluation of 100 ...29. Vij T, Prashar Y, jain D. An updated review on ...30. Patil SB, Magdum C. Phytochemical investigation and antitumour activity of ...31. Raja Sidambaram R, MG Dinesh, Jayalakshmi E. An in vitro ...32. Prakash E, Gupta DK. Cytotoxic Activities of Extracts of Medicinal ...33. Haqa IU, Ullaha N, Bibia G, Kanwala S, Ahmadb MS, ...34. Sreenika G, Naga Sravanthi K, Lakshmi BVS, Thulja P, Sudhakar ...