Copper-phophine catalysted arylation of aromatic aldehydes

Alcohols are very important compounds in the synthesis of drugs, chemicals, flavors and materials used in the agricultural industry.1 They also play as intermediary compounds.2 There are numerous ways for the preparation of secondary alcohols 3 that among them, reduction of diaryl-ketone or addition of organic-metallic reagents to carbonyl-containing compounds are the most important reactions of C-C bond formation in organic syntheses.3 The use of boron reagents 2 as a source of aryl through the exchange of the aryl group between boron and metal is one of the most commonly used methods for aldehyde arylation.In this research, we have investigated the arylation of aromatic aldehydes 1 using high economical, available, active and selective homogeneous catalytic system with copper salts and phosphorus ligands (Scheme 1).The structure of the prepared products was characterized by melting point and spectral analysis techniques IR, 1HNMR, 13CNMR.

Keywords:

Phosphine ligand , Aldehyde , Arylation , Copper salt , Homogenous catalysts