Study the reaction of β-enaminonitriles and perhalopyridines
Publish place: 27th Iranian Seminar on Organic Chemistry
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ISOC27_050
تاریخ نمایه سازی: 19 اسفند 1399
Abstract:
β-enaminonitriles or β- amino acrilonitriles serve as important building blocks in the synthesis of a wide variety of unique heterocyclic systems such as pharmaceuticals, fungicides, and solvatochromatic dyes.1-3 Recently, a number of papers and patents concerning the importance of β-enaminonitriles in the synthesis of biologically active compounds, dihydropyridines analogous to nifedipine and amlodipine as potential calcium channel blockers in the treatment of angina and hypertension have been found.4 They are generally prepared by base-catalyzed Thorpe reaction. Various bases such as sodium alkoxides, lithium ethyl anilide, and lithium diethyl amide are reported for the synthesis of b-enaminonitriles via coupling of aromatic/aliphatic nitriles with active methylenecarbonitriles.5 perhalopyridines as Aromatic heterocycles are widespread and valuable synthetic templates for the preparation of new compounds with specific biological or material properties.6 The structure of compounds were identified by IR, 1H NMR, 13C NMR and 19F NMR spectroscopy.
Keywords:
Authors
Motahare Irani,
Department of Organic Chemistry, Faculty of Chemistry, Vali-e-Asr University, Rafsanjan, Iran
Reza Ranjbar-Karimi,
Department of Organic Chemistry, Faculty of Chemistry, Vali-e-Asr University, Rafsanjan, Iran
Alireza Poorfreidoni,
Department of Organic Chemistry, Faculty of Chemistry, Vali-e-Asr University, Rafsanjan, Iran
Hossein Mehrabi
Department of Organic Chemistry, Faculty of Chemistry, Vali-e-Asr University, Rafsanjan, Iran