Synthesis of thiazepine derivatives using 2-(1, 3-dioxo-1H-inden-2(3H)- ylidene) malononitryl and thiosemicarbazone

Thiazepines and their derivatives are one of the most important heterocyclic compounds, due to the anticonvulsant, antiviral, anticancer, anti-HIV and antitumor effects.1-3 In this study firstly, 2-(1,3-dioxo-1H-indene-2(3H)-yilidene) malononitrile was synthesized from reaction of ninhydrin with malononitril in the ethanol as a solvent at room temperature. Then this intermediate was used for synthesis of thiazepine derivatives using thiosemicarbazone derivatives (Scheme 1). Purification all of the compounds were achieved by recrystallization and were further identified by FT-IR, 1H-NMR, 13C-NMR spectra analysis.

Keywords:

Thiosemicarbazone , Malononitryl , Ninhydrin , Thiazepine