Synthesis of responsive theranostic nanogels

Theranostic nanogels simultaneously carrying both fluorescence-activable probes and therapeutic agents were primarily utilized to investigate drug delivery process. Targeted molecular imaging, an essential component of a theranostic system, can be used to image and track molecular targets involved in disease progression. Nanogels have the characteristics of hydrogels and colloidal nanoparticles such as blood transfusion capability, absorbing a large percentage of water, biocompatibility, high loading capacity and precision of active substances.1-4 In this study, novel redox-sensitive nanogels with theranostic performance to significant abnormalities in the blood were synthesized. The performance of the theranostic system was evaluated in the measurement of hydrogen peroxide in the blood samples of cancerous patients using fluorescence technique. Results revealed that this theranostic nanogel can be used at treatment centers for early diagnosis and treatment of cancer.

Keywords:

Theranostic nanogel , Redox-sensitive , Doxorubicin