Preparation and Characterization of New Inorganic-Organic Hybrid Catalyst and Its Application for Diastereoselective Synthesis of 2-Azapyrrolizidine Alkaloid Scaffolds

Since the development of ordered mesoporous silicas 2, SBA-15 materials developed by Zhao and Stucky serve in many fields due to their interesting textural properties such as appreciable thermal and hydrothermal stability, large pore volume, uniform-sized pores (in the range 4-30 nm) and high special surface area (above 1000 m2/g) 3. We are interested in the development of our research to prepare more effective catalyst to synthesize 2-aza analogue of pyrrolizidine and spirooxindole-2-azapyrrolizidine derivatives. Nano-catalyst W(IV)/NNBIASBA- 15 was prepared by applying simple and cost-effective materials and also it was characterized as a new inorganic-organic hybrid catalyst. The one-pot reaction of aldehyde or isatin (1 mmol), malononitrile (1 mmol), and hydantoin (1 mmol) were catalyzed by W(IV)/NNBIA-SBA-15 in the water. All synthesized compounds are characterized by 1H NMR and IR spectroscopy.

Keywords:

Organic-inorganic hybrid silica , Tetradentate ligand , Multicomponent reaction , Diversity-oriented synthesis.