Improvement of one-pot synthesis of benzothiazole by using methallophthalocyanine as catalyst under solvent-free and microwave conditions

Benzothiazole derivatives are important heterocyclic compunds and due to their biological and pharmacological properties are used in organic and medicinal chemistry.1-2 For example,benzothiazoles are used for antitumor,3 anti-hepatitis C virus4 drugs and industrial applications as vulcanization accelerators and antioxidants. Therefore, in recent years, researchers are interested in preparation and development of benzothiazoles. There are different methods for the synthesis of benzothiazoles. This article reports the condensation reaction between 2-aminothiophenol (1) and different aldehydes (2) by using metallophthalocyanine as efficient and acsessable catalyst and under microwave irradiation (Fig.1). All synthesized compounds characterized by using spectroscopic technique such as: mass spectrum, 1H and 13C NMR and FT-IR spectroscopic data.

Keywords:

Metallophthalocyanine , Benzothiazole , Condensation reaction , Microwave.