Synthesis of highly substituted pyrroles in the presence of cobalt phthalocyanine based catalyst

Among nitrogen containing heterocyclic compounds, pyrrole derivatives are one of the most interesting units in natural products, biological active molecules, and useful building blocks for various functional materials. On the other hand, multicomponent reactions protocol is one the most powerful strategy for the synthesis of versatile molecules through an economic manner. This key tool represents several merits such as good to high yields, minimizing waste, less time consuming and avoidance of costly purification steps, over step by step strategies. In recent times, phthalocyanine based catalysts with metal core, have found divers applications in different fields of science. This elegant position of phthalocyanine based catalyst is due to their thermal and chemical stability and distinct optical and electrical properties. 1-3Herein, we wish to report the synthesis of highly substituted pyrroles in the presence of cobalt phthalocyanine based catalyst (Fig 1).

Keywords:

Synthesis of pyrroles , Cobalt phthalocyanine , Multicomponent reaction