Synthesis of 2,6-Diamino-4-arylpyridine-3,5-dicarbonitrile Derivatives of calix[4]aren via Multicomponent reaction

Six-membered aromatic rings such as pyridine have many useful applications such as drug structure, various biological activity and fluorescence properties.1 2,6-Diamino-4-arylpyridine-3,5-dicarbonitriles are specific category of substituted pyridine derivatives were synthesized by three-component reaction (MCR). The notable features of the conditions of reaction are simplicity, moderate, controllable, catalyst free and easy workup.2The Calixarenes as rigid vase-like molecules are used widespread in several areas of supramolecular chemistry such as macrocyclic receptors for anions, cations, amino acids, small peptide and DNA recognition.3,4In this research, we have focused on the synthesis of a novel lower rim pyridine-calix [4]arenes 4, by the reaction between calix [4] aldehyde 1, malononitrile 2 and ammonium acetate 3 in the reflux conditions. For this aim, the synthesized compounds were characterized by FTIR, 1H NMR.

Keywords:

Multicomponent reactions , 2 , 6-Diamino-4-arylpyridine-3 , 5-dicarbonitrile , catalyst free , supramolecular chemistry , Calixarenes.