Four component synthesis of pyrano[2,3-c]pyrazoles using Ni@zeolite-Y as efficient and recyclable nanocatalyst

The pyrano[2,3-c]pyrazoles are one important class of heterocyclic include nitrogen that exhibit a wide range of pharmacological activities and have broad applications in medicinal.1,2 Additionally, these compounds have been acted as potential insecticidal.3According to importance of pyrano pyrazoles, up to now, different methods have reported for the synthesis of these compounds, the most of these methods despite have some benefit, include some limitations such as, use of toxic solvents, long reaction time, high reaction temperatures, low product yields, multi-stage processes and the use of toxic and expensive catalysts. Therefore, the development of a simple and environmentally benign approach is required to synthesis of this type of heterocyclic compounds. In this regard and looking for our research, 4 we report four-component synthesis of pyranopyrazole derivatives through the reaction between hydrazine, aromatic aldehydes, maleonitrile and ethyl acetoacetate, at 50-60 ℃ by application of mixture of ethanol and water as solvent (Fig 1) and using of Ni-supported on zeolite-Y as green and reusable catalyst.

Keywords:

Ni@zeolite-Y , Nanocatalyst , Pyrano[2 , 3-c]pyrazole , Multi component reaction