SO3H activated zeolite-Y as a nanostructured heterogeneous catalyst for synthesis of tri-substituted imidazoles

Imidazoles are important N-containing heterocycles which have emerged as versatile biologically active compounds possessing applications. Tri-substituted midazoles or 2,4,5-triaryl-1H-imidazoles are generally synthesized in a one-pot three-component condensation of aldehydes, 1,2-diketones, and ammonium acetate. Although various catalysts have been proposed for tri-substituted imidazoles synthesis, exploration for greener and cleaner synthetic strategies still remains as an active research.1-4 Herein, SO3H@zeolite-NaY was used as a green and high active nanocatalyst for the synthesis of tri-substituted imidazole derivatives via solvent-free cyclocondensation of different aldehydes, benzil and ammonium acetate. (Fig 1) This economical chemical procedure has the advantages such as excellent yield in short reaction times, convenient manipulation and high purity of products, the use of nontoxic and heterogeneous acid catalyst with good reusability

Keywords:

Imidazole , Zeolite , Nanocatalyst , Solid acid , Solvent-free