Synthesis and characterization of self-assembled three-dimensional graphene decorated with silica gel

Multicomponent reactions (MCRs), reactions involving at least three starting materials in a one-pot reaction, remain the most efficient method of synthesis of heterocycles.1 Some reagents such as isocyanides are useful reagents for synthesis of organic structures.2 There are many diverse cycloaddition reactions in which isocyanides play a key role for synthesis of different types of heterocycles.3 Five-membered rings such as furan have many useful synthetic applications in drug structures.4 Herein, we report the synthesis of new 2-amino- 5-(cyclohexylamino)-4-arylfuran-3-carbonitriles 4 from the reaction between cyclohexyl isocyanide 1 and aldehydes 2 in the presence of cyanoacetamid 3 at room temperature. All synthesized compounds are stable solids whose structures were determined on the basis of their mass spectrum, 1H and 13C NMR and IR spectroscopic data.