Synthesis, characterization and catalytic evaluation of Fe3O4@SiO2-pr@L-proline for the synthesis of novel derivatives of dihydropyridines

Compounds with dihydropyridines nucleus are a common and important substructures found in natural products and pharmacologically active compounds. They act as glucagon receptor antagonists, inhibitors of P38 MAP kinase, β-Raf kinase, transforming growth factor b1(TGF-b1) type 1 activin receptor-like kinase (ALK5), cyclooxygenase-2 (COX-2), CB1 cannabinoid receptor antagonists, modulators of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR), biosynthesis of interleukin-1 (IL-1). 1 For this reason, synthesis of novel derivatives of dihydropyridines have attracted a lot of interest.Today, catalysts play a significant role in the production of chemicals and nanocatalysts have the potential for improving efficiency, selectivity and yield of the catalytic process. The higher surface to volume ratio means that much more catalyst actively participates in the reaction. Higher selectivity means less waste and fewer impurities, which could lead to safer and reduced environmental impact. 2In continuation of our previous work 3, herein, we specifically address the synthesis and usage of Fe3O4@SiO2-pr@L-proline magnetic nanoparticle as catalyst for the synthesis of new generation of dihydropyridines. All of organic compounds are new and characterized by IR, 1H NMR, 13 C NMR, Mass and elemental analysis.

Keywords:

Green Chemistry , Fe3O4@SiO2-pr@L-proline , dihydropyridines