Application of Fe3O4@SiO2@(CH2)3-urea-benzimidazole sulfonic acid as a separable catalyst the synthesis of pyridines via a cooperative vinylogous anomeric based oxidation for

Pyridine derivatives are one of the most important heterocycles which found in natural products, pharmaceuticals, and functional materials [1]. Among the pyridine systems, 2-amino-3-cyano pyridines are versatile structure which can be applied as intermediates towards the synthesis of varied heterocyclic molecules such as vitamins. They were also reported as novel IKK-b inhibitors, A2A adenosine receptor antagonists, inhibitor of HIV-1 integrase [2]. On the other hand, urea and its derivatives are interesting biological structures which has ubiquitous role in the agriculture industry and pharmaceutical ingredients. In recent years, a series of separable nanomagnetic catalysts based on urea derivatives have been developed [3]. In this work, we applied Fe3O4@SiO2@(CH2)3-urea-benzimidazole sulfonic acid for the synthesis of new 2-amino-3-cyano pyridines via a cooperative vinylogous anomeric based oxidation (Figure 1).

Keywords:

2-Amino-3-cyano pyridine , Cooperative vinylogous anomeric based oxidation